Endocrine Abstracts

Introduction: Diabetes is associated with increased fracture risk both in patients with type 1 (T1D) and type 2 diabetes (T2D) despite differences in bone mineral density BMD (decreased in T1D and increased in T2D). In T2D, insulin resistance (IR) is selective, with some insulin signaling pathways impaired, while others are overactive due to hyperinsulinemia. It is not clear how different insulin signaling pathways might contribute to the bone phenotypes observed in diabetes. ...

99mTc-Sestamibi (SeS) is a standard tool for localization of adenomas/hyperplasia (PA) in hyperparathyroidism (HPTH), designed on the difference between thyroid and parathyroid tissue radiotracer washout on early and late scintigraphy phases. However, PA have been reported to washout as fast as normal thyroid tissue (‘rapid washout’, RW), which may lead to diagnostic failure. The aim of the study was to determine a correlation of RW of SeS from parathyroid...